Jessica Damoiseaux, PhD, an associate professor with the Institute of Gerontology at Wayne State University, recently published the results of a three-year study of cognitive changes in older adults. The team followed 69 primarily African American females, ages 50 to 85, who complained that their cognitive ability was worsening though clinical assessments showed no impairments. Three magnetic resonance imaging scans (MRIs) at 18-month intervals showed significant changes in functional connectivity in two areas of the brain.
“An older adult’s perceived cognitive decline could be an important precursor to dementia,” Damoiseaux said. “Brain alterations that underlie the experience of decline could reflect the progression of incipient dementia and may emerge before cognitive assessment is sensitive enough to detect a deficit.”
The resulting paper is titled, “Longitudinal change in hippocampal and dorsal anterior insulae functional connectivity in subjective cognitive decline.” Damoiseaux conducted the study with graduate student Raymond Viviano, PhD, who is first author.
