AANS Neurosurgeon | Volume 28, Number 2, 2019

Advertisement

Researchers Discover Possible Cause for Alzheimer’s and Traumatic Brain Injury

Print Friendly, PDF & Email

The new mechanism may have also led to the discovery of an effective treatment

Rutgers researchers have discovered a new mechanism that may contribute to Alzheimer’s disease and traumatic brain injury. They now hope to launch a clinical trial to test the treatment in humans.  

What causes Alzheimer’s is unknown, but a popular theory suggests a protein known as amyloid-beta slowly builds up a plaque in the brains of people with Alzheimer’s. But in a recent study Federico Sesti, a professor of neuroscience and cell biology at Rutgers Robert Wood Johnson Medical School, looked at a new mechanism, which involves a non-amyloid-beta protein, a potassium channel referred to as KCNB1.

Under conditions of stress in a brain affected by Alzheimer’s, KCNB1 builds up and becomes toxic to neurons and then promotes the production of amyloid-beta. The build-up of KCNB1 channels is caused by a chemical process commonly known as oxidation.

Click here to read more.

Calendar/Courses

NeuroSafe 2019 Symposium
Aug. 8-9, 2019; Minneapolis

SNSA Congress 2019
Aug. 8-11, 2019; Cape Town, South Africa

2019 Managing Coding and Reimbursement Challenges
Aug. 22-24, 2019; Rosemont, Ill.

Comments are closed.