AANS Neurosurgeon | Volume 29, Number 2, 2020


Researchers Develop Cell Therapy to Improve Memory and Stop Seizures in Mice following Traumatic Brain Injury

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Researchers from the University of California, Irvine developed a breakthrough cell therapy to improve memory and prevent seizures in mice following traumatic brain injury. The study is titled “Transplanted interneurons improve memory precision after traumatic brain injury.” 

Traumatic brain injuries affect 2 million Americans each year and cause cell death and inflammation in the brain. People who experience a head injury often suffer from lifelong memory loss and can develop epilepsy.

In the study, the UCI team transplanted embryonic progenitor cells capable of generating inhibitory interneurons, a specific type of nerve cell that controls the activity of brain circuits, into the brains of mice with traumatic brain injury. They targeted the hippocampus, a brain region responsible for learning and memory.

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