AANS Neurosurgeon | Volume 29, Number 1, 2020

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International Research Team Confirms Potential Glioblastoma Inhibitors

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After diagnosis, only thirty percent of glioblastoma (an aggressive brain cancer) patients have survived more than two years. However, San Diego Supercomputer Center (SDSC) Research Scientist Igor Tsigelny recently collaborated with colleagues from Sweden’s Karolinska Institute and the Pasteur Institute in France to improve the prognosis of those struck with this typically fatal cancer.

The paper, ‘A New Strategy for Designing Allosteric Modulators of Transcription Factor Dimerization’ experimentally confirms researchers’ earlier findings on using interface inhibitors to combat glioblastoma, said Tsigelny.

Tsigelny, who specializes in personalized cancer medicine and computational drug design, previously worked on these interface inhibitors and their role in brain cancer treatment, specifically focused on OLIG2 (oligodendrocyte transcription factor 2), which is primarily known for its relationship with cancers such as glioblastoma and leukemia.

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