AANS Neurosurgeon | Volume 29, Number 2, 2020


Study Suggests Way to Attack Deadly, Untreatable Nerve Tumors

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Scientists Shrink MPNSTs After Cracking Their Genetic Code


Genomic profiling of mostly untreatable and deadly nerve sheath tumors led scientists to test a possible therapeutic strategy that inhibited tumor growth in lab tests on human tumor cells and mouse models.

When the international team of researchers analyzed complete screens of genes and genetic material in malignant peripheral nerve sheath tumors (MPNSTs), it revealed previously unknown genetic information about the disease.

“This uncovered potential therapeutic targets we did not expect for these untreatable tumors, but our findings also need further study before knowing whether they will be relevant to patient treatment in the clinic,” said Q. Richard Lu, PhD, lead author and scientific director of the Brain Tumor Center at the Cincinnati Children’s Cancer and Blood Diseases Institute.

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