AANS Neurosurgeon | Volume 29, Number 2, 2020


Study Reports Possible Novel Method for Stopping Untreatable Pediatric Brain Cancer

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Effective Treatment Options Lacking for Leading Killer of Kids with Cancer


Researchers used an experimental molecular therapy in preclinical laboratory tests to effectively treat several types of deadly pediatric brain cancer and now propose advancing the treatment to clinical testing in children.

Scientists at the Cincinnati Children’s Cancer and Blood Diseases Institute report testing the small molecule 6-thio-2’deoxyguanosine (6-thio-dG) in brain cancer stem cells derived from tumor cells donated by patients. Researchers also tested the treatment in humanized mouse models of pediatric brain cancer.

The cancers include intrinsic pontine glioma (DIPG), high-grade glioma (HGG) and high-risk medulloblastoma (MB).

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