AANS Neurosurgeon | Volume 29, Number 2, 2020


Study Finds Protein Levels in Spinal Fluid Correlate to Posture and Gait Difficulty in Parkinson’s Disease

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Results Published in the Journal Movement Disorders


Levels of a protein found in the brain called alpha-synuclein (?-syn) are significantly lower than normal in cerebrospinal fluid collected in Parkinson’s disease patients suffering from postural instability and gait difficulty, a study led by movement disorders experts at Rush University Medical Center has found. 

“This report is an important contribution in our efforts to understand and quantify Parkinson’s biology to accelerate drug development,” said Mark Frasier, PhD, an author on the study and the senior vice president of research programs at the Michael J. Fox Foundation, which provided funding for the study.

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