AANS Neurosurgeon | Volume 28, Number 3, 2019


Study Cautions Against Use of Bone Morphogenetic Proteins in Children’s Spine Surgery

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Bone morphogenetic proteins, commonly used off-label to enhance pediatric spinal fusion (spinal arthrodesis), did not improve revision rates for pediatric spinal fusion, according to a study. “BMP is frequently used off-label for pediatric spinal fusions, yet children rarely have difficulty forming robust bone at the site of spinal fusion. There is no proof that BMP improves the quality of spinal fusion in children and adolescents,” said lead study author Emily Dodwell, MD, MPH, a pediatric orthopaedic surgeon at  theHospital for Special Surgery (HSS), in New York. “Although the rationale for using BMP is that it might improve bone healing and minimize the likelihood of further surgery, we found that BMP did not change the revision rate in children.”

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