Researchers Probe Brain Disease-Causing Proteins at the Atomic Level
A change in a single amino acid determines which species are vulnerable, study finds
Researchers studying a protein that causes a hereditary degenerative brain disease in humans have discovered that the human, mouse and hamster forms of the protein, which have nearly identical amino acid sequences, exhibit distinct three-dimensional structures at the atomic level.
The protein causes familial human cerebral amyloid angiopathy (CAA), and the study is the first to examine forms of the protein in three different species.
Christopher Jaroniec, professor of chemistry and biochemistry at The Ohio State University, said that the findings highlight the fact that minor alterations in single amino acids can cause profound differences in structure and function among this family of proteins.
Click here to read more.
9th World Congress of Neuroendoscopy
Nov. 21-24, 2019; Orlando, Fla.
Medical and Surgical Interventions in ICH: A Practical Workshop
Nov. 23, 2019; Chicago
2nd International Conference on Brain Stimulation
Nov. 27-28, 2019; Dubai, United Arab Emirates
2019 AANS/CNS Section on Pediatric Neurological Surgery Annual Meeting
Dec. 5-8, 2019; Scottsdale, Ariz.
Dec. 5-8, 2019; Mumbai, India