AANS Neurosurgeon | Volume 28, Number 3, 2019


Promising New Strategy to Attack the Most Lethal Brain Tumor in Children

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Researchers from Northwestern Medicine and Ann & Robert H. Lurie Children’s Hospital of Chicago have revealed new insight into how the most deadly pediatric brain tumor, diffuse intrinsic pontine glioma (DIPG), may develop. They also have identified a compound that targets the “on” switch for cancer-promoting genes, which resulted in shrinking tumor size and increased survival in an animal model of DIPG. Preparations for a clinical trial at Lurie Children’s are now under way. Their findings bring new hope to children with this devastating brain tumor. Unlike some other brain tumors, only 5 percent of children with DIPG are surviving two years after diagnosis. Currently the standard treatment is radiation therapy, which temporarily decreases symptoms but does not cure the disease.

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