AANS Neurosurgeon | Volume 28, Number 2, 2019


PID1 Gene Enhances Effectiveness of Chemotherapy on Brain Cancer Cells

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Investigators at The Saban Research Institute of Children’s Hospital Los Angeles have found that the gene PID1 enhances killing of medulloblastoma and glioblastoma cells. Medulloblastoma is the most commonly occurring malignant primary brain tumor in children; glioblastoma is the most commonly occurring malignant primary brain tumor in adults. Historically, chemotherapy played a small role in the treatment of brain tumors. Research done in the last decade has shown that certain tumors of the brain and spinal cord, are sensitive to chemotherapy. The PID1 gene was discovered during this period and was investigated for its role in metabolic disease. Anat Erdreich-Epstein, MD, PhD, a physician-scientist specializing in pediatric brain cancers at CHLA, published the first report on the role of PID1 in cancer – establishing that it suppressed growth of medulloblastoma and glioma cells. The current study builds on this work.

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