AANS Neurosurgeon | Volume 28, Number 3, 2019

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New Study: Traumatic Brain Injury Causes Intestinal Damage

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Two-Way Brain-Gut Interactions May Worsen Outcome After TBI

University of Maryland School of Medicine (UMSOM) researchers have found a two-way link between traumatic brain injury (TBI) and intestinal changes. These interactions may contribute to increased infections in these patients, and may also worsen chronic brain damage.

This is the first study to find that TBI in mice can trigger delayed, long-term changes in the colon and that subsequent bacterial infections in the gastrointestinal system can increase posttraumatic brain inflammation and associated tissue loss.

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