New Gene Identified in Lou Gehrig’s Disease
Newly revealed disease mechanism points to a potential target for treatment
For the first time, a variant in UBQLN4 gene has been associated with Lou Gehrig’s disease or amyotrophic lateral sclerosis (ALS) – a progressive disease resulting in the loss of nerve cells that control muscle movement, which eventually leads to paralysis and death. The study also describes how this gene variant disrupts a cellular process that drives motor neuron development. This new insight opens the door to potential treatment targets for ALS. “We know that many genes are involved in ALS and a major goal in the field is to identify as many of these genes as we can so we can uncover targets for treatment at the cellular level,” says lead author Brittany Edens from Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago. “We found that UBQLN4 gene variant interferes with a pathway involved in breaking down a certain protein called beta catenin, and the resulting accumulation of this protein leads to defects in the motor neuron structure. These defects likely make motor neurons vulnerable to progressive degeneration seen in ALS.”
Click here to read more.
Microsurgical and Radiological Anatomy of Cerebral Sulci, Gyri, and Ventricles: The Rhoton-de Oliveira Course for Surgical Applications
Nov. 13-15, 2019; Jacksonville, Fla.
Complex Endoscopic Endonasal Surgery of the Skull Base
Nov. 14-16, 2019; Pittsburgh
2019 New Frontiers in the Diagnosis and Management of Movement Disorders
Nov. 16, 2019; Chicago
9th World Congress of Neuroendoscopy
Nov. 21-24, 2019; Orlando, Fla.
Mayo Clinic Multidisciplinary Spine Care Conference 2019
Nov. 22-23, 2019; Amelia Island, Fla.