International Guidelines for Traumatic Brain Injury Management: Implementation in Low- and Middle-income Countries

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The Brain Trauma Foundation (BTF) Guidelines for the Management of Traumatic Brain Injury have been considered the gold standard document for evidence-based interventions in TBI care worldwide (1). Since their introduction in the late 90s, other international guidelines have been published with similar structure or just as an adaptation or adoption process (2–7).

Most of these guidelines have been developed in high income countries (HIC’s), were advanced technology for neuromonitoring is available. Unfortunately, some of these devices are not worldwide available and limits the application of some recommendations, including a barrier for defining thresholds for urgent decision making (8). This current situation creates a critical gap in knowledge transferability when it is required to adapt or develop local protocols, especially in low- and middle-income countries (LMIC´s) (Figure 1).

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Figure 1. A: International neurotrauma fellows using basic surgical tools for performing emergency neurosurgery when no electric or pneumatic craniotomes are available. B: Cranioplasty performed with hand molded acrylic powder as an option when customed implants are not available. C: International Neurotrauma Fellow and a 5th year neurosurgery resident from Europe performing burr holes with a “Hudson” brace for an emergency case involving a Chronic Subdural Hematoma. Source: authors.

Guidelines and Protocols from HIC’s and LMIC’s

We present a summary of the main international HIC’s and LMIC’s guidelines in Table 1, including the link for their complete access (1-7) (9-11). Then, in Table 2 we describe Guidelines, Consensus and Protocols that has been developed with the aim of address the gaps in knowledge transferability for the management of TBI cases were not all the resources are available (12-15), including the recent BOOTStraP Consensus, that define stratified protocols for applying it according to the available resources and training level for near to 10 different scenarios for Prehospital (EMS), Emergency Room (ER), Intensive Care Unit (ICU) or Operation Room (OR) (Figure 2) (15).

Figure 2. Scheme for understanding the interaction of the stratified protocols consensus (BootStrap). Protocols for different levels of EMS response integrate with protocols for different levels of ER (with or without CT) and then the ER protocols interact with different levels of OR (with or without a neurosurgeon) or ICU (with or without advanced monitoring systems). Source: Reference 15 with permission.

Table 1. Main international guidelines from HIC’s and LMIC’s.

High-income Countries

  

Guideline Title

Country

Year of publication

Guidelines for the Management of Severe Head Injury, 2nd EditionJapan2012
Guidelines for the management of severe head injury. Part 1. Neurotrauma system and neuroimaging.Russia2015
Guidelines for the diagnosis and treatment of severe traumatic brain injury. Part 2. Intensive care and neuromonitoringRussia2016
Guidelines for the management of severe traumatic brain injury. Part 3. Surgical management of severe traumatic brain injuryRussia2016
Clinical practice guidelines in severe traumatic brain injury in TaiwanTaiwan2009
Guidelines for the Management of Severe Traumatic Brain Injury, Fourth Edition: Update of the Brain Trauma Foundation Guidelines, Executive SummaryUSA2016
EBIC-guidelines for management of severe head injury in adults. European Brain Injury ConsortiumEurope1997

Low and Middle-income Countries

Clinical Practice Guideline Diagnosis and treatment of adult patients with severe Traumatic Brain InjuryColombia2014
Guías Clínicas, Traumatismo Encéfalo Craneano Moderado o Grave. MINSAL ChileChile2013
Traumatic brain injury Multi Organizational Consensus Recommendations for IndiaIndia2014

 

Table 2. International guidelines and protocols for specific situations in TBI patients

Guidelines for Specific TBI Situations (Remote Locations, TBI with Polytrauma)

Name of guideline

Country

Year of publication

The management of acute neurotrauma in rural and remote locations: A set of guidelines for the care of head and spinal injuries 3rd editionAustralasia2009
WSES consensus conference guidelines: monitoring and management of severe adult traumatic brain injury patients with polytrauma in the first 24 hoursMulti-country authors2019

Protocols / Consensus for Specific TBI Situations (No ICP Availability, Different Resources Levels)

Consensus-Based Management Protocol (CREVICE Protocol) for the Treatment of Severe Traumatic Brain Injury Based on Imaging and Clinical Examination for Use When Intracranial Pressure Monitoring Is Not EmployedMulti-country authors2020
Recommendations of the Colombian Consensus Committee for the Management of Traumatic Brain Injury in Prehospital, Emergency Department, Surgery, and Intensive Care (Beyond One Option for Treatment of Traumatic Brain Injury: A Stratified Protocol [BOOTStraP])Colombia2020

Traumatic brain injury management is a critical intervention for tackling one of the main diseases associated with the bigger burden of death and disability worldwide. Several guidelines, consensus and protocols have been proposed, mostly developed in HIC’s. Knowledge transferability barriers have been identified when applying international guidelines in LMIC´s. Recently some specific guidelines, consensus, and protocols, oriented for decision making in areas were not all the resources exists have been developed. The stratification of care according to the level of resources and training is opening a new era in consensus and protocol development for a global application.

References

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