AANS Neurosurgeon | Volume 26, Number 3, 2017

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Scientists Find New Path in brain to Ease Depression

Promising new target for antidepressants to help those where others have failed

Northwestern Medicine scientists have discovered a new pathway in the brain that can be manipulated to alleviate depression. The pathway offers a promising new target for developing a drug that could be effective in individuals for whom other antidepressants have failed. 

New antidepressant options are important because a significant number of patients do no adequately improve with currently available antidepressant drugs. The lifetime prevalence of major depressive disorder is between 10 to 20 percent of the population.

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