AANS Neurosurgeon | Volume 26, Number 2, 2017

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Old Drug Could Fight Brain Cancer by Starving It to Death

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New research targets the most common form of deadly brain cancer, glioblastoma. Currently, there is no cure for this type of tumor. However, this study aims to shut down the sugar availability to the cancer cells in hopes of inhibiting further tumor growth. What makes glioblastoma cells so interesting is their ability to reprogram their metabolism to rely on a high uptake of glucose to sustain the cells’ malignant activity. By using a drug known as flavopirid that inactivates the enzyme glycogen phosphorylase, these researchers think they could cut the tumor cells off at the source so to speak. “This points toward a new possible use of this compound of flavopiridol-derived formulations in combination with anti-proliferative agents in glioblastoma patients.” To read more, click here.

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