AANS Neurosurgeon | Volume 27, Number 2, 2018

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Men and Women have Different Genetic Risk Factors for Developing Brain Cancer

New international study points the way to genetic tests that could assess risk

 

Glioma is the most common type of primary malignant brain tumor in the United States; glioblastoma being the most common type of glioma in adults. While sex differences in the incidence and survival rates of glioma were known, researchers had not investigated whether genetic differences based on sex could cast light on potential differences in the risk profile of glioma between men and women.

Now, a team from Case Western Reserve University School of Medicine, together with an international consortium of researchers, have discovered that men and women have different genetic risk factors for developing glioma.

The study involved the work of more than 35 investigators representing more than 30 universities, institutes and government agencies worldwide.

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