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AANS Neurosurgeon | Volume 26, Number 1, 2017

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Good Cells Gone Bad

TSRI Scientists Discover PINK-SNO[W]

A new study from The Scripps Research Institute (TSRI) is the first to show precisely how a process in nerve cells called the S-nitrosylation (SNO) reaction—which can be caused by aging, pesticides and pollution—may contribute to Parkinson’s disease.

The leader of the study, TSRI Professor Stuart Lipton, M.D., Ph.D., is now investigating how new pharmaceuticals might counteract this harmful S-nitrosylation reaction.

“The new finding gives us a clue as to where to intervene,” said Lipton, who holds a joint position at the University of California, San Diego, School of Medicine, where he is a practicing clinical neurologist involved in the care of Parkinson’s patients.

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