You are viewing AANS Neurosurgeon Volume 25, Number 4, 2016. View our current issue, Volume 26, Number 2, 2017

AANS Neurosurgeon | Volume 25, Number 4, 2016

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Drug Improves Brain Performance in Rett Syndrome Mice

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After learning that a small-molecule drug improves breathing in a mouse model of the neurodevelopmental disorder Rett syndrome, University of Alabama at Birmingham researcher Lucas Pozzo-Miller, Ph.D., wondered if he could test it on other brain functions.

Pozzo-Miller has now found that the brain penetrant drug — a small-molecule mimetic of BDNF, or brain derived neurotrophic factor — is able to improve brain performance in Rett syndrome mice — specifically synaptic plasticity in the hippocampus and object location memory. The hippocampus is involved in learning and memory.

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