AANS Neurosurgeon | Volume 26, Number 3, 2017

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Drug Improves Brain Performance in Rett Syndrome Mice

After learning that a small-molecule drug improves breathing in a mouse model of the neurodevelopmental disorder Rett syndrome, University of Alabama at Birmingham researcher Lucas Pozzo-Miller, Ph.D., wondered if he could test it on other brain functions.

Pozzo-Miller has now found that the brain penetrant drug — a small-molecule mimetic of BDNF, or brain derived neurotrophic factor — is able to improve brain performance in Rett syndrome mice — specifically synaptic plasticity in the hippocampus and object location memory. The hippocampus is involved in learning and memory.

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Calendar/Courses

15th Annual WCIRDC California
Nov. 30-Dec. 2, 2017; Universal City, Calif.

Miami Brain Symposium
Dec. 1, 2017; Coral Gables, FL

Interactive Calendar

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