AANS Neurosurgeon | Volume 26, Number 2, 2017

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Blocking Key Enzyme Halts Parkinson's Disease Symptoms in Mice

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In this study, researchers believe they have been able to identify two important clues to fight Parkinson’s disease. The first being that blocking the enzyme c-AbI prevents the disease from occurring in specially bred mice. The second includes placing a tag on a second protein that can signal the presence and progression of the disease. “There were indications that c-AbI activity leads to Parkinson’s disease, and our experiments show there is indeed a connection,” says Ted Dawson, MD, PhD, professor of neurology and director of the Institute for Cell Engineering at the Johns Hopkins University School of Medicine. “There is already a Food and Drug Administration-approved c-AbI inhibiting drug in use for leukemia,” he adds, “so we’re interested in whether it could be used safely against Parkinson’s disease or as a starting point to develop other treatments.” To read more, click here.

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