You are viewing AANS Neurosurgeon Volume 28, Number 3, 2019. View our current issue, Volume 29, Number 2, 2020

AANS Neurosurgeon | Volume 28, Number 3, 2019

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Study Shows Patients with Hemorrhagic Brain Disease Have Disordered Gut Microbiomes

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A new study shows that people with a rare genetic disease that causes bleeding in the brain have gut microbiomes distinct from those without the disease. Moreover, it is the molecules produced by this bacterial imbalance that cause lesions to form in the brains of these patients.

The results are the first in any human neurovascular disease. They have implications both for treating the disease and in examining other neurovascular diseases that could be affected by a person’s gut microbiome.

The study was led by investigators at University of Chicago Medicine. It examined the gut bacteria of patients with cavernous angioma (CA), a disease where blood vessel abnormalities develop in the brain and cause strokes, seizures and serious neurologic complications. The disease is caused by a genetic mutation in the lesion —which may be inherited or occurs sporadically — and its severity and course vary widely among patients.

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