SLU Researcher Hones in on Plaque-causing Protein in ALS and Dementia
In a recent paper, Yuna Ayala, PhD, assistant professor of biochemistry and molecular biology at Saint Louis University (SLU), and her research team made advances in understanding how a protein causes damaging plaques to build up in neurodegenerative illnesses like amyotrophic lateral sclerosis (ALS) and a form of dementia called frontotemporal lobar degeneration. Ayala and her lab study TDP-43, a protein that binds to RNA and plays a role in gene expression. In 2006, researchers discovered that TDP-43 was the main feature of neurological disorders like ALS and frontotemporal dementia. DP-43 is an important protein tied to cell survival, metabolism and function that has been conserved by evolution in animals from flies to humans. Without TDP-43, scientists see animals develop locomotive defects and shortened lifespans.
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14th International Conference on Neurology, Neuroscience and Neuromuscular Disorders
June 17-18, 2019; Tokyo
CARS 2019 Computer Assisted Radiology and Surgery
June 18-21, 2019; Rennes, France
18th Meeting of WSSFN
June 24-27, 2019; New York
International Summer School Transnasal Endoscopic Surgery: From Sinuses to Skull Base
June 24-28, 2019; Brescia, Italy
The Society of University Neurosurgeons Annual Meeting
June 26-30, 2019; Dubrovnik, Croatia