Seattle Children’s Opens Immunotherapy Trial For Children With Relapsed Central Nervous System Tumors That Delivers CAR T Cells Directly Into the Brain

0
1357

CAR T-cell immunotherapy targeting HER2 protein on cancer cells aims to provide children and young adults who have limited treatment options with a second line of defense

 

Seattle Children’s has opened a pioneering chimeric antigen receptor (CAR) T-cell immunotherapy trial for children and young adults with relapsed or refractory HER2-positive central nervous system (CNS) tumors where CAR T cells will be delivered directly into the brain. In the phase I trial, BrainChild-01, cancer-fighting CAR T cells will be infused through a catheter, either into the cavity where the tumor has been removed or the CNS ventricular system, depending on the location of the tumor.

o

CNS tumors, which are found in the brain and spine, are the most common form of childhood cancer and are the leading cause of cancer-related death in children under the age of 19. More than 4,000 children in the U.S. are diagnosed with brain tumors each year. While approximately 70% of children with newly diagnosed CNS tumors survive with standard therapy, the disease is often fatal for the approximately 30% of children who relapse.

Click here to read more.

Print Friendly, PDF & Email
o