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AANS Neurosurgeon | Volume 28, Number 1, 2019

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Researchers Map Protein-Gene Interactions Involved in Alzheimer’s Disease

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Among the confounding challenges of diagnosing and treating Alzheimer’s disease (AD) is the fact that patients with asymptomatic and symptomatic versions of the degenerative condition may share similar neuropathological burdens but experience significantly different rates of cognitive decline. 

In a new study, a team led by researchers at University of California San Diego School of Medicine used the transcriptome — the sum of all messenger RNA (mRNA) molecules expressed from genes — to compare 414 study participants with clinically diagnosed and neuropathologically confirmed AD with an age-matched, non-demented control group from a community-based neuropathological study.

Their findings suggest that integrating protein interactions with gene perturbations can generate a comprehensive framework for characterizing alterations in the molecular network related to AD. 

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