Protein Called GRASP1 is Needed to Strengthen Brain Circuits
Learning and memory depend on cells’ ability to strengthen and weaken circuits in the brain. Now, researchers at Johns Hopkins Medicine report that a protein involved in recycling other cell proteins plays an important role in this process. Removing this protein reduced mice’s ability to learn and recall information. “We see deficits in learning tasks,” says Richard Huganir, PhD, professor and director of the neuroscience department at the Johns Hopkins University School of Medicine. The team also found mutations in the gene that produces the recycling protein in a few patients with intellectual disability, and those genetic errors affected neural connections when introduced into mouse brain cells. The results suggest that the protein could be a potential target for drugs to treat cognitive disorders such as intellectual disability and autism, Huganir says.
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14th International Conference on Neurology, Neuroscience and Neuromuscular Disorders
June 17-18, 2019; Tokyo
CARS 2019 Computer Assisted Radiology and Surgery
June 18-21, 2019; Rennes, France
18th Meeting of WSSFN
June 24-27, 2019; New York
International Summer School Transnasal Endoscopic Surgery: From Sinuses to Skull Base
June 24-28, 2019; Brescia, Italy
The Society of University Neurosurgeons Annual Meeting
June 26-30, 2019; Dubrovnik, Croatia