One type of brain cell may invite Alzheimer’s

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Research on toxic proteins could drive treatment strategies

Better tactics for detecting, preventing and treating Alzheimer’s disease depend on a clearer understanding of cellular-level changes in the minds of patients, and a new study has uncovered novel details about the vulnerability of one type of brain cell. 

Researchers found that excitatory neurons – those that are more likely to trigger an action (as opposed to inhibitory neurons, which are less likely to prompt neural activity) – are more vulnerable to accumulations of abnormal tau protein, which is increasingly being implicated in Alzheimer’s disease. 

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The study also uncovered some possible genetic explanations for the vulnerability of those cells, work that has the potential to one day lead to targeted treatment. 

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