New Player in Alzheimer’s Disease Pathogenesis Identified
Findings may provide new direction for discovery of therapeutics
Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have shown that a protein called membralin is critical for keeping Alzheimer’s disease pathology in check. The study shows that membralin regulates the cell’s machinery for producing beta-amyloid (or amyloid beta, A?), the protein that causes neurons to die in Alzheimer’s disease.
“Our results suggest a new path toward future treatments for Alzheimer’s disease,” says Huaxi Xu, Ph.D., the Jeanne and Gary Herberger Leadership Chair of SBP’s Neuroscience and Aging Research Center. “If we can find molecules that modulate membralin, or identify its role in the cellular protein disposal machinery known as the endoplasmic reticulum-associated degradation (ERAD) system, this may put the brakes on neurodegeneration.”
Click here to read more.
5th International Conference on Spine and Spinal Disorders
April 25-26, 2019; Rome
2019 Annual MNNS Meeting
April 27, 2019; St. Paul, Minn.
GOODMAN Oral Board Preparation Course
May 1-3, 2019; Glendale, Ariz.
6th Annual Advanced Practice Provider Pediatric Neurosurgery Conference
May 2-3, 2019; Cincinnati
2019 Comprehensive Stroke Symposium
May 3-4, 2019; Rockville, Md.