You are viewing AANS Neurosurgeon Volume 28, Number 1, 2019. View our current issue, Volume 28, Number 4, 2019

AANS Neurosurgeon | Volume 28, Number 1, 2019

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Genes Associated With Resilience Against Brain Pathology Identified

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Two genes help cognition withstand damage in brain from Alzheimer’s

The pathologies (damage) in the brain that stroke, Alzheimer’s disease and other neurological conditions cause in older adults only partially explain the memory loss, reduced reasoning ability and other cognitive impairments that result from these conditions. Little is known about why the effects of brain pathology vary between people who develop it. Now researchers have discovered two genes, known as UNC5C and ENC1, that are associated with aging individuals having better memory and brain function than would be expected, given the amount of pathologies that accumulated in their brains. “Most of the cognitive loss that we experience in older age remains unexplained. Certain individuals are very resistant to the pathologies of the aging brain, while others may be particularly vulnerable,” says study senior investigator David Bennett, MD, who directs the Rush Alzheimer’s Disease Center.

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Calendar/Courses

Bypass 2020 – Anniversary Symposium
Jan. 8-10, 2020; Switzerland Frauenklinikstrass, Switzerland

Sun Valley Stroke Conference 2020
Jan. 9-12, 2020; Sun Valley, Idaho

Kranzler Chicago Review Course in Neurosurgery
Jan. 24-31, 2020; Chicago

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