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AANS Neurosurgeon | Volume 27, Number 3, 2018

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Deletion of a Stem Cell Factor Promotes TBI Recovery in Mice

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UT Southwestern molecular biologists today report the unexpected finding that selectively deleting a stem cell transcription factor in adult mice promotes recovery after traumatic brain injury (TBI).

The Centers for Disease Control and Prevention defines TBI as a bump, blow, or jolt to the head that disrupts normal brain function, ranging from mild – brief changes in mental status – to severe, marked by an extended period of unconsciousness or memory loss. In humans, most TBIs are mild and are called concussions.

“Our results reveal that SOX2-dependent signaling pathways in reactive astrocytes are targets for brain recovery after traumatic injury,” said Dr. Chun-Li Zhang, Associate Professor of Molecular Biology and in the Hamon Center for Regenerative Science and Medicine. Dr. Zhang is co-corresponding author of the study.

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