AANS Neurosurgeon | Volume 29, Number 1, 2020


Blood Biomarkers May Allow Easier Detection, Confirmation of Concussions

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UCI, Georgetown and Rochester study may lead to reliable diagnostics


Researchers from the University of California, Irvine, Georgetown University and the University of Rochester have found that specific small molecules in blood plasma may be useful in determining whether someone has sustained a mild traumatic brain injury (mTBI), commonly known as a concussion. 

Six specific small molecules from blood plasma were discovered in a group of college athletes who had been diagnosed with concussions. When these molecules were assessed, their combined presence accurately predicted whether teammates had sustained an mTBI or not. This suggests that these small molecules, and possibly others, might be clinically relevant biomarkers of mTBI. The same six biomarkers were then tested in a separate group of individuals, without and with mTBI, and the results replicated the athlete findings.

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David Crafts | May 17, 2018 at 8:26 pm

Time course of these molecules? Is any finding of them diagnostic, or is there a baseline level?