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AANS Neurosurgeon | Volume 27, Number 2, 2018


Biology of Childhood Brain Tumor Subtypes Offers Clues to Precision Treatments

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CHOP Researchers Reveal Differences among Gene Fusions in Low-Grade Pediatric Brain Tumors


Researchers investigating pediatric low-grade gliomas (PLGG), the most common type of brain tumor in children, have discovered key biological differences in how mutated genes combine with other genes to drive this childhood cancer. By shedding light on subtle distinctions in tumor biology, these findings offer clues to designing more effective anticancer treatments to precisely target tumors in individual patients.

“Carefully defining the molecular landscape of these tumor subtypes may guide us in pediatric precision medicine, to better treat children with brain tumors,” said Payal Jain, PhD, a postdoctoral researcher at Children’s Hospital of Philadelphia (CHOP).

Jain, a former graduate student in the Perelman School of Medicine at the University of Pennsylvania, is the first author of two recent PLGG studies, with colleagues from CHOP, Penn and other institutions.

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