Backbone of Success
More than 20 years ago, the lab of developmental biologist Olivier Pourquié discovered a sort of cellular clock in chicken embryos where each “tick” stimulates the formation of a structure called a somite that ultimately becomes a vertebra.
In the ensuing years, Pourquié and others further illuminated the mechanics of this so-called segmentation clock across many organisms, including creation of the first models of the clock in a lab dish using mouse cells.
While the work has improved knowledge of normal and abnormal spine development, no one has been able to confirm whether the clock exists in humans — until now.
Pourquié led one of two teams that have now created the first lab-dish models of the segmentation clock that using stem cells derived from adult human tissue.
The achievements not only provide the first evidence that the segmentation clock ticks in humans but also give the scientific community the first in vitro systems enabling the study of very early spine development in humans.
2020 Winter Clinics for Cranial & Spinal Surgery
Feb. 23-27, 2020; Snowmass Village, Colo.
71st Annual Meeting of the Southern Neurosurgical Society
Feb. 26-29, 2020; Richmond, Va.
3rd Annual Mayo Clinic Advances and Innovations in Complex Neuroscience Patient Care: Brain and Spine 2020
Feb. 27-29, 2020; Sedona, Ariz.
Multidisciplinary Neuro-Oncology Symposium: Updates in Medical and Surgical Management of Brain Tumors
March 6-7, 2020; Orlando, Fla.
5th Annual Safety in Spine Surgery Summit
March 12-13, 2020; New York
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