Altitude Sickness Drug Appears to Slow Progression of Glioblastoma
Acetazolamide increased sensitivity to treatment and enhanced survival in mice
A drug used to treat altitude sickness — as well as glaucoma, epilepsy, heart failure and seizures — may also offer significant gains for patients with a fast-growing brain tumor known as glioblastoma, according to a study.
The drug, acetazolamide, sold under the trade name Diamox, is “cheap to make, easy to take and has limited side effects,” said study director Bahktiar Yamini, MD, a professor of neurosurgery at the University of Chicago Medicine.
“I take it myself, whenever I go to the Rocky Mountains,” he said, “two pills a day.” The most common side effect of Diamox is “a metallic taste when drinking something carbonated.”
The most frequently used chemotherapy for gliomas is a drug called temozolomide (TMZ). However, not all patients respond to this drug. Median survival with this disease is about 14 months.
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14th International Conference on Neurology, Neuroscience and Neuromuscular Disorders
June 17-18, 2019; Tokyo
CARS 2019 Computer Assisted Radiology and Surgery
June 18-21, 2019; Rennes, France
18th Meeting of WSSFN
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International Summer School Transnasal Endoscopic Surgery: From Sinuses to Skull Base
June 24-28, 2019; Brescia, Italy
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June 26-30, 2019; Dubrovnik, Croatia