Zeroing in on Dopamine

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Study in mice identifies the molecular machinery responsible for dopamine release in the brain

 

Studied for decades for its critical role in movement control and reward-seeking behaviors, the neurotransmitter dopamine has been the focus of numerous efforts to understand its activity, particularly when it goes awry in disorders such as Parkinson’s and addiction.

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While researchers have made great strides, less is known about the mechanisms that healthy dopamine cells use to release the neurotransmitter, a gap that has limited scientists’ ability to develop treatments for a range of dopamine-related conditions.  

Now, researchers from Harvard Medical School have for the first time identified the molecular machinery responsible for the precise secretion of dopamine in the brain.

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