AANS Neurosurgeon | Volume 27, Number 2, 2018


UCI, Queensland Scientists Identify New Switch to Boost Memory

Findings may lead to a better understanding of memory-related disorders

In this study, researchers, led by Timothy Bredy, UCI associate professor, discovered that adding methyl groups to RNA strengthened memory formation. This process, known as methylation, modifies RNA and affects how it functions within a cell. When the researchers reduced the enzyme that removes methyl groups from RNA, memory formation was boosted. “By genetically silencing an enzyme in a specific region of the brain involved in memory and adaptive behavior, we saw much better memory recall in mice,” said Jocelyn Widagdo, postdoctoral fellow and co-lead author of the study from Queensland Brain Institute in Australia. To read more, click here.

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