AANS Neurosurgeon | Volume 26, Number 1, 2017

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What Turns Benign Central Nervous System Tumors Deadly

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More than one in three tumors that affect the central nervous system are meningiomas and most are benign. However, some can turn deadly. In a new study, Yale researchers identified genetic abnormalities that mark atypical meningiomas, which have a 40 percent chance of recurring after surgical removal and are marked by a shorter survival rate than benign tumors. The new genetic analysis has identified molecular mechanisms involved in the formation of primary atypical meningiomas. “The tumor cells behave more like stem cells. They are less specialized and divide rapidly,” said Yale’s Akdes Serin Harmanci, the first author of the paper.

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