AANS Neurosurgeon | Volume 27, Number 2, 2018


Too Much 'Noise' can Affect Brain Development

UCI study may help to better understand developmental disorders

In an effort to improve improve our understanding of developmental disorders, scientists at the University of California, Irvine (UCI), have determined that uncontrolled fluctuations, known as ‘noise’ in the concentration of Retinoic acid (RA) can lead to disruptions in the brain during development. RA is a very important secreted molecule in the brain that aids in proper brain organization. How cells in the brain respond to RA and its ‘noise’ depend on its production, movement through tissue and interactions with many proteins within the cell. During normal development, cells can filter out this ‘noise’ and continue moving forward with normal development. However, when a protein that aids in this process is altered or missing, the cells could no longer control the level of ‘noise’ which then led to disruptions in brain development and organization. To read more on this study, click here

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