AANS Neurosurgeon | Volume 27, Number 1, 2018

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Study Shows Potential for New Glioblastoma Treatment

A completely new treatment for glioblastoma, which combines a common chemotherapy agent with T cells, may enter clinical trials following highly successful mouse-model studies. Researchers with the Jonsson Comprehensive Cancer Center at the University of California, Los Angeles reported in the journal Neuro-Oncology that this new hybrid treatment has successfully passed all animal studies and is being considered for clinical trials in humans due to its apparent lower risks combined with improved outcomes. The treatment is recommended for fast-growing tumors following surgery in order to prevent the highly common relapses found following glioblastoma removals. “By treating glioblastoma cells with decitabine, we found that we can unmask targets on the tumor cell that can be recognized by killer T cells,” he adds. “Once these targets are uncovered, we can then administer T cells that are genetically programmed to attack tumor cells with the new targets.” To learn more about this study, click here.

Calendar/Courses

Second International Brain Mapping Course
April 26-27, 2018; New Orleans

Surgical Approaches to Skull Base
April 26-28, 2018; St. Louis, MO

2018 AANS Annual Scientific Meeting
April 28-May 2, 2018; New Orleans

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