SLU Researcher Hones in on Plaque-causing Protein in ALS and Dementia
In a recent paper, Yuna Ayala, PhD, assistant professor of biochemistry and molecular biology at Saint Louis University (SLU), and her research team made advances in understanding how a protein causes damaging plaques to build up in neurodegenerative illnesses like amyotrophic lateral sclerosis (ALS) and a form of dementia called frontotemporal lobar degeneration. Ayala and her lab study TDP-43, a protein that binds to RNA and plays a role in gene expression. In 2006, researchers discovered that TDP-43 was the main feature of neurological disorders like ALS and frontotemporal dementia. DP-43 is an important protein tied to cell survival, metabolism and function that has been conserved by evolution in animals from flies to humans. Without TDP-43, scientists see animals develop locomotive defects and shortened lifespans.
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GOODMAN Oral Board Preparation Course Tumor
Nov. 1-3, 2017; Glendale, Ariz.
June 29-30, 2017; Germany
The Society of University Neurosurgeons Annual Meeting
July 27-Aug. 3, 2017; South Africa
Washington University/St. Louis Children’s Comprehensive SEEG Course
Aug. 10-12, 2017; St. Louis
Tennessee Neurological Society Annual Meeting
Aug. 11-12, 2017; Nashville, Tenn.
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