AANS Neurosurgeon | Volume 26, Number 1, 2017

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Scoliosis Linked to Disruptions in Spinal Fluid Flow

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Gene mutations may be the cause of irregular flow of fluid through the spinal column that could then cause scoliosis as shown in a study in zebrafish. This type of scoliosis can affect humans during adolescence. These mutated genes damage the cilia within the spinal canal and that leads to the curvature of the spine. “This is the first hint of a biological mechanism for idiopathic scoliosis,” said Rebecca Burdine, associate professor of molecular biology at Princeton, and a senior author of the study. “We hope this research will open up new areas of inquiry as to how the disruptions to normal cerebrospinal fluid ¬†flow can lead to spinal curvature.” To read more, click here.

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