AANS Neurosurgeon | Volume 26, Number 2, 2017

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Sac to the Future: Cellular Vessels Predict Likelihood of Developing Dementia

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Blood-based neuronally-derived exosomes carry tell-tale proteins that could help forecast transition from mild cognitive impairment to Alzheimer’s disease

In this study, researchers have found that tiny micro-vesicle structures that are used by neurons and other cells carry signs to help predict the likelihood of mild cognitive impairment (MCI). These structures transport materials internally or dispose of them externally. “MCI is often a transitional stage between normal aging and dementia,” said senior author Robert A. Rissman, PhD, associate professor in the Department of Neurosciences at UC San Diego School of Medicine, director of the Biomarker Core for the Alzheimer’s Disease Cooperative Study (ADCS) and director of the Neuropathology Core and Brain Bank for the UC San Diego Shiley-Marcos Alzheimer’s Disease Research Center. “It’s associated with more minor cognitive impairment and carries and increased risk of developing Alzheimer’s dementia.” To read more, click here.

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