Risk of Developing Alzheimer’s Disease Linked to a Network of Genes Associated With Myeloid Cells
Many genes linked to late-onset Alzheimer’s disease (AD) are expressed in myeloid cells and regulated by a single protein, according to research conducted at the Icahn School of Medicine at Mount Sinai. Mount Sinai researchers led an international, genome-wide study of more than 40,000 people with and without the disease and found that innate immune cells of the myeloid lineage play an even more central role in Alzheimer’s disease pathogenesis than previously thought. Specifically, the research team identified a network of genes that are implicated in AD and expressed by myeloid cells, innate immune cells that include microglia and macrophages. Furthermore, researchers identified the transcription factor PU.1, a protein that regulates gene expression and, thus, cell identity and function, as a master regulator of this gene network.
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8th Annual EANS Young Neurosurgeons Meeting and EANS Research Course
March 22, 2018 - March 24, 2018; Oxford, United Kingdom
The Society of University Neurosurgeons Annual Meeting
March 22, 2018 - March 25, 2018; Dallas
ASN 2018 Annual Meeting
March 24-28, 2018; Riverside, CA
3rd Annual Principles and Techniques of Complex Spinal Reconstruction: A Hands-on Cadaveric Workshop
March 30, 2018 - March 31, 2018; New York
11th Annual Cervical Spine Research Society Hands-on Cadaver Course
April 12-14, 2018; St. Louis, MO