AANS Neurosurgeon | Volume 26, Number 1, 2017


Reward, Aversion Behaviors Activated Through Same Brain Pathways

Bookmark and Share

Findings recently published in the journal Neuron may help explain why drug treatments for addiction and depression don’t work for some patients. The results of the study suggest that the treatments for both may simultaneously stimulate reward and aversion responses in the brain, resulting in a net effect of zero for some patients. “We studied the neurons that cause activation of kappa opioid receptors, which are involved in every kind of addiction — alcohol, nicotine, cocaine, heroin, methamphetamine,” said the principal investigator of the study. “We produced opposite reward and aversion behaviors by activating neuronal populations located very near one another. This might help explain why drug treatments for addiction don’t always work — they could be working in these two regions at the same time and canceling out any effects.” By understanding how the receptors work, researchers may be able to more specifically target drug therapies to treat conditions linked to reward and aversion responses in the brain. To read more about this study, click here.


Microsurgery Course Zurich
March 29-April 1, 2017; Zurich, Switzerland

12th World Congress on Brain Injury
March 29-April 1, 2017; New Orleans

2017 National Neuroscience Review
March 31-April 1, 2017; National Harbor, Md.

Brain & Brain PET 2017
April 1-4, 2017; Berlin, Germany

Neurosurgical Society of America Annual Meeting 2017
April 2-5, 2017; Jacksonville, Fla.

Interactive Calendar

Comments are closed.