AANS Neurosurgeon | Volume 26, Number 1, 2017

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Researchers Find That Immune Cells Play Unexpected Role in Lou Gehrig's Disease

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Findings raise hope for new ALS treatments that target immune cell dysfunction

A new hope for ALS therapies has been found by research scientists at Cedars-Sinai. These new therapies are said to target the neurodegenerative disease that leads to paralysis and death in patients who have been diagnosed. During this study, researchers focused on the genetic mutation that causes ALS as well as frontotemporal dementia. This is another neurological disorder that can lead to change in personality, behavior and language. “The C9orf72 gene is critical for the function of immune cells in the brain, adding to growing evidence that the brain’s immune system actively contributes to disease rather than simply responding to injury,” said Robert H. Baloh, MD, PhD, senior author of the study and director of Neuromuscular Medicine in the Department of Neurology and the multidisciplinary ALS Program at Cedars-Sinai. “These findings continue a paradigm shift in the way we think of how brain cells are lost in conditions like ALS and Alzheimer’s disease.” Click here to read more. 

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