Researchers Find Potential Therapy for Brain Swelling During Concussion
Biomedical engineering researchers pre-treated cells that swell after traumatic injury with an existing, FDA-approved drug
A team of biomedical engineering researchers at the University of Arkansas have identified a cause of fluid swelling of the brain, or cellular edema, that occurs during a concussion. The researchers discovered that pre-treating the cells with an existing, FDA-approved drug used for epilepsy and altitude sickness reduces the expression of a specific protein that causes swelling. “Out study found that mild traumatic brain injury resulted in increased expression of a protein called aquaporin-4, which caused a massive cellular influx of fluid, leading to increased astrocyte cell volume and injury,” said Kartik Balachandran, assistant professor of biomedical engineering. “We then worked with a drug called Acetazolamide. Our results showed that Acetazolamide minimized cell swelling and injury, suggesting a therapeutic role for this drug in reducing the detrimental effects of concussions.” Click here to read more.
GOODMAN Oral Board Preparation Course Tumor
Nov. 1-3, 2017; Glendale, Ariz.
Computer Assisted Radiology and Surgery 31st International Congress and Exhibition
June 20-24, 2017; Barcelona, Spain
2017 New England Neurological Society Annual Meeting
June 22-24, 2017; Chatham, Mass.