AANS Neurosurgeon | Volume 27, Number 1, 2018


Regulation of Parkinson's Disease Inflammatory Responses by a MicroRNA

According to a University of Alabama at Birmingham (UAB) study, a small regulatory RNA called microRNA-155 appears to play a key role in brain inflammation that is associated with Parkinson’s disease. Using a mouse model, researchers found microRNA-155 is both a potential therapeutic target and biomarker for Parkinson’s disease. Parkinson’s disease affects as many as 1 million Americans, even more than multiple sclerosis, muscular dystrophy and Lou Gehrig’s disease combined. Thousands of cases are not diagnosed and go undetected. Parkinson’s disease can progress for years while going undetected. The UAB researchers, led by David Standaert, MD, PhD, professor and chair of the UAB Department of Neurology, write that their results “suggest that microRNA-155 is involved early in Parkinson’s disease pathogenesis and is important for initiating the inflammatory response to alpha-synuclein.” Click here to read more. 


Second International Brain Mapping Course
April 26-27, 2018; New Orleans

Surgical Approaches to Skull Base
April 26-28, 2018; St. Louis, MO

2018 AANS Annual Scientific Meeting
April 28-May 2, 2018; New Orleans

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