Regulation of Parkinson's Disease Inflammatory Responses by a MicroRNA
According to a University of Alabama at Birmingham (UAB) study, a small regulatory RNA called microRNA-155 appears to play a key role in brain inflammation that is associated with Parkinson’s disease. Using a mouse model, researchers found microRNA-155 is both a potential therapeutic target and biomarker for Parkinson’s disease. Parkinson’s disease affects as many as 1 million Americans, even more than multiple sclerosis, muscular dystrophy and Lou Gehrig’s disease combined. Thousands of cases are not diagnosed and go undetected. Parkinson’s disease can progress for years while going undetected. The UAB researchers, led by David Standaert, MD, PhD, professor and chair of the UAB Department of Neurology, write that their results “suggest that microRNA-155 is involved early in Parkinson’s disease pathogenesis and is important for initiating the inflammatory response to alpha-synuclein.” Click here to read more.
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