AANS Neurosurgeon | Volume 26, Number 4, 2017


Penn-led Team Presents Results From Clinical Trial of Personalized Cellular Therapy in Brain Tumor Patients

Investigational “hunter” T cells expand in blood and traffic to glioblastoma tumors

This study was created from an interdisciplinary collaboration of neurosurgeons, neuro-oncologists, neuropathologists, immunologists and transfusion medical experts. Each played a key role in its development. They engineered immune cells to seek out and attack glioblastomas (GBM) in patients. During their study, they found that these engineered immune cells were found to have acceptable safety profiles and were able to successfully migrate and infiltrate tumors. “One of the main questions in the field of T cell therapies is: can we make this work in solid tumors?” Maus said. “The barriers to CAR T cells in solid tumors are identifying targets with acceptable safety profiles, proving that T cells can get out of the blood, and that they can successfully target the tumor cells expressing the antigen without being turned off by the tumor environment.” Click here to read more. 


Winter Clinics for Cranial and Spinal Surgery
Feb. 25, 2018 - Mar. 1, 2018; Snowmass Village, Colo.

69th Southern Neurosurgical Society Annual Meeting
Feb. 28, 2018 - Mar. 3, 2018; San Juan, PR

Second International Brain Mapping Course
April 26-27, 2018; New Orleans

Comments are closed.