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AANS Neurosurgeon | Volume 25, Number 3, 2016


Newly Discovered Biomarkers May Lead to Promising Diagnostic Tool for Alzheimer’s

Approach could offer stage-specific prognosis, open door to better treatment


Diagnosing Alzheimer’s disease and determining a patient’s prognosis is an inexact business, and that stands in the way of better personalized care and advances in treatment. 

First, the team of researchers discovered new physical biomarkers that could help pinpoint a diagnosis – changes to proteins found in the spinal fluid and blood of patients. In particular, as Alzheimer’s severity increased, the proteins were longer, more rigid and more clustered, said lead researcher Mingjun Zhang, a professor of biomedical engineering at Ohio State.

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