AANS Neurosurgeon | Volume 26, Number 3, 2017

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New Research Identifies Molecules That Could Help to Prevent the Development of Brain Tumours

Researchers from the University of Portsmouth’s Brain Tumour Research Centre of Excellence have identified molecules which are responsible for metastatic lung cancer cells binding to blood vessels in the brain.

In order for a cancer cell to enter the brain, it must first bind to the cells which line the structure separating the blood from the brain which is called the blood-brain barrier (BBB). Such information about the factors associated with this process may provide a way of preventing the cancer cells binding to the BBB and crossing over into the brain.

Twenty to 40 percent of patients with non-small cell lung cancer (NSCLC) develop brain metastasis.

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